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Malaria journal DOI:10.1186/1475-2875-13-34

Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.

Publication TypeJournal Article
Year of Publication2014
AuthorsDeme, AB, Park, DJ, Bei, AK, Sarr, O, Badiane, AS, Gueye Pel, H, Ahouidi, A, Ndir, O, Mboup, S, Wirth, DF, Ndiaye, D, Volkman, SK
JournalMalaria journal
Date Published2014/01/29

The Senegalese National Malaria Control Programme has recommended use of rapid diagnostic tests (RDTs) that target the histidine-rich protein 2 (HRP2), specific to Plasmodium falciparum, to diagnose malaria cases. The target antigen has been shown to be polymorphic, which may explain the variability in HRP2-based RDT results reported in field studies. The genetic diversity of the pfhrp2 gene has not been investigated in depth in many African countries. The goal of this study is to determine the extent of polymorphism in pfhrp2 among Senegal, Mali and Uganda parasite populations, and discuss the implications of these findings on the utility of RDTs that are based on HRP2 detection.