|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Ostacher, MJ, Iosifescu, DV, Hay, A, Blumenthal, SR, Sklar, P, Perlis, RH|
|Date Published||2014 Mar|
|Keywords||Adult, Bipolar Disorder, Calcium Channel Blockers, Calcium Channels, L-Type, Female, Genome-Wide Association Study, Humans, Isradipine, Male, Middle Aged, Pilot Projects, Psychiatric Status Rating Scales|
OBJECTIVES: Motivated by genetic association data implicating L-type calcium channels in bipolar disorder liability, we sought to estimate the tolerability, safety, and efficacy of isradipine in the adjunctive treatment of bipolar depression.
METHODS: A total of 12 patients with bipolar I or II depression entered this pilot, proof-of-concept eight-week investigation and 10 returned for at least one post-baseline visit. They were initiated on isradipine at 2.5 mg and titrated up to 10 mg daily, with blinded assessments of depression using the Montgomery-Åsberg Depression Rating Scale (MADRS) as well as adverse effects.
RESULTS: Among the 10 patients, three had bipolar II disorder; all but two reported current episode duration longer than six months. In all, four of 10 completed the study; no significant adverse events were observed, although one subject discontinued treatment per protocol because of possible hypomanic symptoms which had resolved prior to study visit. In a mixed-effects model, mean improvement in depression severity, assessed by MADRS, was 2.1 (standard error = 0.36) points/week (p
CONCLUSIONS: Isradipine merits further investigation for the treatment of bipolar depression. This preliminary trial illustrates the potential utility of genetic investigation in identifying psychiatric treatment targets.
|Alternate Journal||Bipolar Disord|