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Journal of Crohn's & colitis DOI:10.1016/j.crohns.2014.01.003

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.

Publication TypeJournal Article
Year of Publication2014
AuthorsFowler, SA, Ananthakrishnan, AN, Gardet, A, Stevens, CR, Korzenik, JR, Sands, BE, Daly, MJ, Xavier, RJ, Yajnik, V
JournalJournal of Crohn's & colitis
Date Published2014/01/22

More than 80% of Crohn's disease (CD) patients will require surgery. Surgery is not curative and rates of re-operation are high. Identification of genetic variants associated with repeat surgery would allow risk stratification of patients who may benefit from early aggressive therapy and/or post-operative prophylactic treatment.