You are here

Nature methods DOI:10.1038/nmeth.2815

Epigenome-wide association studies without the need for cell-type composition.

Publication TypeJournal Article
Year of Publication2014
AuthorsZou, J, Lippert, C, Heckerman, D, Aryee, M, Listgarten, J
JournalNature methods
Date Published2014/01/26

In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition-information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from