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Nat Methods DOI:10.1038/nmeth.2815

Epigenome-wide association studies without the need for cell-type composition.

Publication TypeJournal Article
Year of Publication2014
AuthorsZou, J, Lippert, C, Heckerman, D, Aryee, M, Listgarten, J
JournalNat Methods
Volume11
Issue3
Pages309-11
Date Published2014 Mar
ISSN1548-7105
KeywordsCells, Epigenomics, Genome-Wide Association Study, Humans, Linear Models
Abstract

In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition--information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from http://www.microsoft.com/science/.

URLhttp://dx.doi.org/10.1038/nmeth.2815
DOI10.1038/nmeth.2815
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24464286?dopt=Abstract

Alternate JournalNat. Methods
PubMed ID24464286