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Stroke; a journal of cerebral circulation DOI:10.1161/STROKEAHA.113.002938

Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case-Control and Prospective Cohort Studies.

Publication TypeJournal Article
Year of Publication2014
AuthorsMalik, R, Bevan, S, Nalls, MA, Holliday, EG, Devan, WJ, Cheng, YC, Ibrahim-Verbaas, CA, Verhaaren, BF, Bis, JC, Joon, AY, Destefano, AL, Fornage, M, Psaty, BM, Ikram, MA, Launer, LJ, van Duijn, CM, Sharma, P, Mitchell, BD, Rosand, J, Meschia, JF, Levi, C, Rothwell, PM, Sudlow, C, Markus, HS, Seshadri, S, Dichgans, M, Wellcome Trust Case Control Consortium, 2
JournalStroke; a journal of cerebral circulation
Date Published2014/01/16

Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts.