Scientific Publications

The multilayered complexity of ceRNA crosstalk and competition.

Publication TypeJournal Article
AuthorsTay, Y., Rinn J., and Pandolfi PP
AbstractRecent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
Year of Publication2014
JournalNature
Volume505
Issue7483
Pages344-52
Date Published (YYYY/MM/DD)2014/01/16
ISSN Number0028-0836
DOI10.1038/nature12986
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24429633?dopt=Abstract