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The multilayered complexity of ceRNA crosstalk and competition.
|Publication Type||Journal Article|
|Authors||Tay, Y., Rinn J., and Pandolfi PP|
|Abstract||Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.|
|Year of Publication||2014|
|Date Published (YYYY/MM/DD)||2014/01/16|