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Nature DOI:10.1038/nature12986

The multilayered complexity of ceRNA crosstalk and competition.

Publication TypeJournal Article
Year of Publication2014
AuthorsTay, Y, Rinn, J, Pandolfi, PPaolo
JournalNature
Volume505
Issue7483
Pages344-52
Date Published2014 Jan 16
ISSN1476-4687
KeywordsAnimals, Argonaute Proteins, Binding, Competitive, Humans, MicroRNAs, Pseudogenes, RNA, RNA Editing, RNA, Long Noncoding, RNA, Messenger, RNA-Binding Proteins
Abstract

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

URLhttp://dx.doi.org/10.1038/nature12986
DOI10.1038/nature12986
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24429633?dopt=Abstract

Alternate JournalNature
PubMed ID24429633
PubMed Central IDPMC4113481
Grant ListR01 CA082328 / CA / NCI NIH HHS / United States
R01 CA170158 / CA / NCI NIH HHS / United States
R01 CA-82328 / CA / NCI NIH HHS / United States