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Nat Neurosci DOI:10.1038/nn.3610

Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.

Publication TypeJournal Article
Year of Publication2014
AuthorsMerkle, FT, Fuentealba, LC, Sanders, TA, Magno, L, Kessaris, N, Alvarez-Buylla, A
JournalNat Neurosci
Date Published2014 Feb
KeywordsAge Factors, Animals, Cerebral Ventricles, Gene Expression Regulation, Developmental, Glial Fibrillary Acidic Protein, Green Fluorescent Proteins, Homeodomain Proteins, Interneurons, Kruppel-Like Transcription Factors, Membrane Microdomains, Mice, Neural Stem Cells, Neuroglia, RNA, Untranslated, Transcription Factors, Transduction, Genetic, Zinc Finger Protein GLI1

Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb. The full extent of diversity among adult NSCs and their progeny is not known. Here, we report the generation of at least four previously unknown olfactory bulb interneuron subtypes that are produced in finely patterned progenitor domains in the anterior ventral V-SVZ of both the neonatal and adult mouse brain. Progenitors of these interneurons are responsive to sonic hedgehog and are organized into microdomains that correlate with the expression domains of the Nkx6.2 and Zic family of transcription factors. This work reveals an unexpected degree of complexity in the specification and patterning of NSCs in the postnatal mouse brain.


Alternate JournalNat. Neurosci.
PubMed ID24362763
PubMed Central IDPMC4100623
Grant ListR01 NS028478 / NS / NINDS NIH HHS / United States
207807 / / European Research Council / International
86419 / / Medical Research Council / United Kingdom
G0501173 / / Medical Research Council / United Kingdom
HD 32116 / HD / NICHD NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R37 HD032116 / HD / NICHD NIH HHS / United States
NS 28478 / NS / NINDS NIH HHS / United States
R37 NS028478 / NS / NINDS NIH HHS / United States
R01 HD032116 / HD / NICHD NIH HHS / United States