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Journal of the National Cancer Institute DOI:10.1093/jnci/djt331

Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations.

Publication TypeJournal Article
Year of Publication2013
AuthorsNan, H, Morikawa, T, Suuriniemi, M, Imamura, Y, Werner, L, Kuchiba, A, Yamauchi, M, Hunter, DJ, Kraft, P, Giovannucci, EL, Fuchs, CS, Ogino, S, Freedman, ML, Chan, AT
JournalJournal of the National Cancer Institute
Volume105
Issue24
Pages1852-61
Date Published2013/12/18
ISSN0027-8874
Abstract

Regular aspirin use reduces the risk for colorectal cancer (CRC), possibly through inhibition of WNT/cadherin-associated protein β1 (CTNNB1 or β-catenin) signaling. The single nucleotide polymorphism (SNP) rs6983267 on chromosome 8q24 is a CRC susceptibility locus that affects binding activity of transcription factor 7 like-2 (TCF7L2) to CTNNB1, thereby altering expression of target oncogenes, including MYC.

URLhttp://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=24317174
DOI10.1093/jnci/djt331
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24317174?dopt=Abstract