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Neuropsychopharmacology DOI:10.1038/npp.2013.181

Revitalizing psychiatric therapeutics.

Publication TypeJournal Article
Year of Publication2014
AuthorsHyman, SE
JournalNeuropsychopharmacology
Volume39
Issue1
Pages220-9
Date Published2014 Jan
ISSN1740-634X
KeywordsAnimals, Biomarkers, Disease Models, Animal, Drug Discovery, Humans, Mental Disorders, Models, Neurological, Molecular Targeted Therapy
Abstract

Despite high prevalence and enormous unmet medical need, the pharmaceutical industry has recently de-emphasized neuropsychiatric disorders as 'too difficult' a challenge to warrant major investment. Here I describe major obstacles to drug discovery and development including a lack of new molecular targets, shortcomings of current animal models, and the lack of biomarkers for clinical trials. My major focus, however, is on new technologies and scientific approaches to neuropsychiatric disorders that give promise for revitalizing therapeutics and may thus answer industry's concerns.

URLhttp://dx.doi.org/10.1038/npp.2013.181
DOI10.1038/npp.2013.181
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24317307?dopt=Abstract

Alternate JournalNeuropsychopharmacology
PubMed ID24317307
PubMed Central IDPMC3857646