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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology DOI:10.1038/npp.2013.181

Revitalizing psychiatric therapeutics.

Publication TypeJournal Article
Year of Publication2014
AuthorsHyman, SE
JournalNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume39
Issue1
Pages220-9
Date Published2014/01/01
ISSN0893-133X
Abstract

Despite high prevalence and enormous unmet medical need, the pharmaceutical industry has recently de-emphasized neuropsychiatric disorders as 'too difficult' a challenge to warrant major investment. Here I describe major obstacles to drug discovery and development including a lack of new molecular targets, shortcomings of current animal models, and the lack of biomarkers for clinical trials. My major focus, however, is on new technologies and scientific approaches to neuropsychiatric disorders that give promise for revitalizing therapeutics and may thus answer industry's concerns.

URLhttp://dx.doi.org/10.1038/npp.2013.181
DOI10.1038/npp.2013.181
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24317307?dopt=Abstract