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Nat Struct Mol Biol DOI:10.1038/nsmb.2728

Poly-combing the genome for RNA.

Publication TypeJournal Article
Year of Publication2013
AuthorsGoff, LA, Rinn, JL
JournalNat Struct Mol Biol
Volume20
Issue12
Pages1344-6
Date Published2013 Dec
ISSN1545-9985
KeywordsAnimals, Embryonic Stem Cells, Humans, Polycomb Repressive Complex 2, Promoter Regions, Genetic, RNA, Messenger, RNA-Binding Proteins
Abstract

An unresolved question in mammalian epigenetic regulation is how ubiquitously expressed chromatin-modifying complexes such as Polycomb group complex 2 (PRC2) find their specific target sites across an intricate choreography of localization events in time and space. Two recent studies now provide critical new insights into an intriguing genome-wide role for RNA in PRC2 regulation.

URLhttp://dx.doi.org/10.1038/nsmb.2728
DOI10.1038/nsmb.2728
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24304912?dopt=Abstract

Alternate JournalNat. Struct. Mol. Biol.
PubMed ID24304912