Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Cell Rep
Authors
Abstract

Selenium (Se) is an essential trace element because of its presence in selenoproteins in the form of selenocysteine residue. Both Se deficiency, which compromises selenoprotein functions, and excess Se, which is toxic, have been associated with altered redox homeostasis and adverse health conditions. Surprisingly, we found that, although Se deficiency led to a drastic decline in selenoprotein expression, mice subjected to this dietary regimen for their entire life had normal lifespans. To understand the molecular mechanisms involved, we performed systemic analyses at the level of metabolome, transcriptome, and microRNA profiling. These analyses revealed that Se deficiency reduced amino acid levels, elevated mononucleotides, altered metabolism, and activated signaling pathways linked to longevity-related nutrient sensing. The data show that the metabolic control associated with nutrient sensing coordinately responds to suppressed selenoprotein functions, resulting in normal lifespan under Se deficiency.

Year of Publication
2019
Journal
Cell Rep
Volume
27
Issue
9
Pages
2785-2797.e3
Date Published
2019 May 28
ISSN
2211-1247
DOI
10.1016/j.celrep.2019.05.001
PubMed ID
31141699
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