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Annual review of medicine DOI:10.1146/annurev-med-060712-200152

DNA Sequencing of Cancer: What Have We Learned?

Publication TypeJournal Article
Year of Publication2013
AuthorsChmielecki, J, Meyerson, M
JournalAnnual review of medicine
Date Published2013/11/20

DNA sequencing has taught us much about the structure of cancer genomes and enabled the discovery of novel genes that drive and maintain tumorigenesis. With the advent and application of next-generation massively parallel sequencing technologies, one can rapidly generate and analyze data from the cellular "-omes": genomes, exomes, and transcriptomes. This review highlights recent genomic discoveries in signal transduction, metabolism, epigenetic modifications, cell cycle and genome maintenance,RNAprocessing, and transcription. Additionally, genomic sequencing has revealed the complexity of the cancer genome and has enabled the discovery of functional rearrangements with therapeutic and diagnostic potentials. Expected final online publication date for the Annual Review of Medicine Volume 65 is January 14, 2014. Please see for revised estimates.