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PLoS Genet DOI:10.1371/journal.pgen.1003926

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.

Publication TypeJournal Article
Year of Publication2013
AuthorsPatsopoulos, NA, Barcellos, LF, Hintzen, RQ, Schaefer, C, van Duijn, CM, Noble, JA, Raj, T, Gourraud, P-A, Stranger, BE, Oksenberg, J, Olsson, T, Taylor, BV, Sawcer, S, Hafler, DA, Carrington, M, De Jager, PL, de Bakker, PIW
Corporate AuthorsIMSGC, ANZgene
JournalPLoS Genet
Date Published2013 Nov
KeywordsAlleles, Chromosome Mapping, Genetic Predisposition to Disease, Genome-Wide Association Study, Haplotypes, Histocompatibility Antigens Class I, HLA-DP beta-Chains, HLA-DRB1 Chains, Humans, Linkage Disequilibrium, Major Histocompatibility Complex, Membrane Proteins, Multiple Sclerosis, Polymorphism, Single Nucleotide, Receptors, Tumor Necrosis Factor, Type I

The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP data from genome-wide studies, we imputed and tested classical alleles and amino acid polymorphisms in 8 classical human leukocyte antigen (HLA) genes in 5,091 cases and 9,595 controls. We identified 11 statistically independent effects overall: 6 HLA-DRB1 and one DPB1 alleles in class II, one HLA-A and two B alleles in class I, and one signal in a region spanning from MICB to LST1. This genomic segment does not contain any HLA class I or II genes and provides robust evidence for the involvement of a non-HLA risk allele within the MHC. Interestingly, this region contains the TNF gene, the cognate ligand of the well-validated TNFRSF1A MS susceptibility gene. The classical HLA effects can be explained to some extent by polymorphic amino acid positions in the peptide-binding grooves. This study dissects the independent effects in the MHC, a critical region for MS susceptibility that harbors multiple risk alleles.


Alternate JournalPLoS Genet.
PubMed ID24278027
PubMed Central IDPMC3836799
Grant ListR01 NS049477 / NS / NINDS NIH HHS / United States
NIH/NIAID R01AI076544 / / PHS HHS / United States
R01NS0495103 / NS / NINDS NIH HHS / United States
R01NS026799 / NS / NINDS NIH HHS / United States
NIH/NINDS R01NS049510 / NS / NINDS NIH HHS / United States
HHSN261200800001E / / PHS HHS / United States
R01 NS026799 / NS / NINDS NIH HHS / United States
R01NS049477 / NS / NINDS NIH HHS / United States