You are here

Stroke DOI:10.1161/STROKEAHA.113.002707

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

Publication TypeJournal Article
Year of Publication2014
AuthorsDichgans, M, Malik, R, König, IR, Rosand, J, Clarke, R, Gretarsdottir, S, Thorleifsson, G, Mitchell, BD, Assimes, TL, Levi, C, O'Donnell, CJ, Fornage, M, Thorsteinsdottir, U, Psaty, BM, Hengstenberg, C, Seshadri, S, Erdmann, J, Bis, JC, Peters, A, Boncoraglio, GB, März, W, Meschia, JF, Kathiresan, S, M Ikram, A, McPherson, R, Stefansson, K, Sudlow, C, Reilly, MP, Thompson, JR, Sharma, P, Hopewell, JC, Chambers, JC, Watkins, H, Rothwell, PM, Roberts, R, Markus, HS, Samani, NJ, Farrall, M, Schunkert, H
Corporate AuthorsMETASTROKE Consortium, CARDIoGRAM Consortium, C4D Consortium, International Stroke Genetics Consortium
JournalStroke
Volume45
Issue1
Pages24-36
Date Published2014 Jan
ISSN1524-4628
KeywordsBrain Ischemia, Coronary Artery Disease, Data Interpretation, Statistical, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide, Reproducibility of Results, Risk Factors, Stroke
Abstract

BACKGROUND AND PURPOSE: Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases.

METHODS: Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P

RESULTS: Common variants associated with CAD at P

CONCLUSIONS: Our results demonstrate substantial overlap in the genetic risk of IS and particularly the LAS subtype with CAD.

URLhttp://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=24262325
DOI10.1161/STROKEAHA.113.002707
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24262325?dopt=Abstract

Alternate JournalStroke
PubMed ID24262325
PubMed Central IDPMC4112102
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
090532/Z/09/Z / / Wellcome Trust / United Kingdom
HHSN268201100012C / HL / NHLBI NIH HHS / United States
P01 HL087018 / HL / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
UL1 RR033176 / RR / NCRR NIH HHS / United States
U01 HG 004446 / HG / NHGRI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
084723/Z/08/Z / / Wellcome Trust / United Kingdom
Z01 AG000015 / AG / NIA NIH HHS / United States
R01 HL089650 / HL / NHLBI NIH HHS / United States
UL1RR033176 / RR / NCRR NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
R01 NS45012 / NS / NINDS NIH HHS / United States
R01 NS045012 / NS / NINDS NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
R01 NS042733 / NS / NINDS NIH HHS / United States
N01AG12100 / AG / NIA NIH HHS / United States
U01 HG004446 / HG / NHGRI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
HHSN268 201100011C / / PHS HHS / United States
R01 HL087647 / HL / NHLBI NIH HHS / United States
095626 / / Wellcome Trust / United Kingdom
R01 HL103931 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
R01 AG015928 / AG / NIA NIH HHS / United States
SP/04/002 / / British Heart Foundation / United Kingdom
HHSN268201100008C / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
R01 HL087676 / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
R01H L59367 / / PHS HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HL105756 / HL / NHLBI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
R01 HL085251 / HL / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
Z01 AG-000015-50 / AG / NIA NIH HHS / United States
R56 AG020098 / AG / NIA NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
G0700931 / / Medical Research Council / United Kingdom
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
N01 HC085085 / HC / NHLBI NIH HHS / United States
AG033193 / AG / NIA NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
AG-20098 / AG / NIA NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
P01 HL076491 / HL / NHLBI NIH HHS / United States
HL087652 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
MC_U137686857 / / Medical Research Council / United Kingdom
N01-HC-85086 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
R01 DK080732 / DK / NIDDK NIH HHS / United States
R01-HL087641 / HL / NHLBI NIH HHS / United States
R01 HL093029 / HL / NHLBI NIH HHS / United States
NS17950 / NS / NINDS NIH HHS / United States
R01DK080732 / DK / NIDDK NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
RE/08/004 / / British Heart Foundation / United Kingdom
AG-027058 / AG / NIA NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
R01 NS-42733 / NS / NINDS NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
HHSN268200782096C / HG / NHGRI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
HHSN268201200036C / HL / NHLBI NIH HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
U01 NS069208 / NS / NINDS NIH HHS / United States
R01 NS039987 / NS / NINDS NIH HHS / United States
P01 HL098055 / HL / NHLBI NIH HHS / United States
P01HL087018 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
R01-HL093029 / HL / NHLBI NIH HHS / United States
HL93029 / HL / NHLBI NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
090532 / / Wellcome Trust / United Kingdom
N01-HC-75150 / HC / NHLBI NIH HHS / United States
1R01HL103931-01 / HL / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
WT084724MA / / Wellcome Trust / United Kingdom
Z01 AG-000954-06 / AG / NIA NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 HL080295 / HL / NHLBI NIH HHS / United States
MOP-82810 / / Canadian Institutes of Health Research / Canada
ZIA HL006002-06 / / Intramural NIH HHS / United States
085475/B/08/Z / / Wellcome Trust / United Kingdom
G0601966 / / Medical Research Council / United Kingdom
HHSN268201100007C / / PHS HHS / United States
HHSN26820110 0008C / / PHS HHS / United States
R01HL089650-02 / HL / NHLBI NIH HHS / United States
MOP172605 / / Canadian Institutes of Health Research / Canada
N01 HC085084 / HC / NHLBI NIH HHS / United States
R01 AG020098 / AG / NIA NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01HC85082 / HL / NHLBI NIH HHS / United States
U01 HG004436 / HG / NHGRI NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
N01HC85083 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
Z99 HL999999 / / Intramural NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
075491/Z/04 / / Wellcome Trust / United Kingdom
HHSN268201100007I / HL / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
HHSN268201200036C / / PHS HHS / United States
U01 NS069208-01 / NS / NINDS NIH HHS / United States
HHSN268200782096C / / PHS HHS / United States
HL080295 / HL / NHLBI NIH HHS / United States
N01-HC-85239 / HC / NHLBI NIH HHS / United States
MOP77682 / / Canadian Institutes of Health Research / Canada
HL087647 / HL / NHLBI NIH HHS / United States
AG-023629 / AG / NIA NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
HL-093029 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
R01 HL073410 / HL / NHLBI NIH HHS / United States
R01 AG027058 / AG / NIA NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
N01HC85080 / HL / NHLBI NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
R56 AG023629 / AG / NIA NIH HHS / United States
U54 RR020278 / RR / NCRR NIH HHS / United States
085475/Z/08/Z / / Wellcome Trust / United Kingdom
Z01 AG000954 / AG / NIA NIH HHS / United States
R01 NS-39987 / NS / NINDS NIH HHS / United States
N01HC85081 / HL / NHLBI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
P01HL076491-06 / HL / NHLBI NIH HHS / United States