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Trends Cell Biol DOI:10.1016/j.tcb.2013.09.011

The use of small molecules in somatic-cell reprogramming.

Publication TypeJournal Article
Year of Publication2014
AuthorsFederation, AJ, Bradner, JE, Meissner, A
JournalTrends Cell Biol
Volume24
Issue3
Pages179-87
Date Published2014 Mar
ISSN1879-3088
KeywordsCell Differentiation, Cellular Reprogramming, Humans, Induced Pluripotent Stem Cells, Transcription Factors
Abstract

Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by transcription factors share a common history starting with the early AZA and MyoD experiments in fibroblast cells. Recent work shows that a combination of small molecules can replace all of the reprogramming factors and many previous studies have demonstrated their use in enhancing efficiencies or replacing individual factors. Here we provide a brief introduction to reprogramming followed by a detailed review of the major classes of small molecules that have been used to date and what future opportunities can be expected from these.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0962-8924(13)00168-2
DOI10.1016/j.tcb.2013.09.011
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24183602?dopt=Abstract

Alternate JournalTrends Cell Biol.
PubMed ID24183602
PubMed Central IDPMC3943685
Grant ListP01 GM099117 / GM / NIGMS NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States