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The use of small molecules in somatic-cell reprogramming.
|Publication Type||Journal Article|
|Authors||Federation, AJ, Bradner JE, and Meissner A.|
|Abstract||Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by transcription factors share a common history starting with the early AZA and MyoD experiments in fibroblast cells. Recent work shows that a combination of small molecules can replace all of the reprogramming factors and many previous studies have demonstrated their use in enhancing efficiencies or replacing individual factors. Here we provide a brief introduction to reprogramming followed by a detailed review of the major classes of small molecules that have been used to date and what future opportunities can be expected from these.|
|Year of Publication||2013|
|Journal||Trends in cell biology|
|Date Published (YYYY/MM/DD)||2013/10/30|