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Nat Genet DOI:10.1038/ng.2795

Common variants associated with plasma triglycerides and risk for coronary artery disease.

Publication TypeJournal Article
Year of Publication2013
AuthorsDo, R, Willer, CJ, Schmidt, EM, Sengupta, S, Gao, C, Peloso, GM, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, ML, Mora, S, Beckmann, JS, Bragg-Gresham, JL, Chang, H-Y, Demirkan, A, Hertog, HMDen, Donnelly, LA, Ehret, GB, Esko, T, Feitosa, MF, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, RM, Freitag, DF, Gurdasani, D, Heikkilä, K, Hyppönen, E, Isaacs, A, Jackson, AU, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, ME, Li, X, Luan, J'an, Lyytikäinen, L-P, Magnusson, PKE, Mangino, M, Mihailov, E, Montasser, ME, Müller-Nurasyid, M, Nolte, IM, O'Connell, JR, Palmer, CD, Perola, M, Petersen, A-K, Sanna, S, Saxena, R, Service, SK, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, RJ, Surakka, I, Tanaka, T, Teslovich, TM, Thorleifsson, G, Van den Herik, EG, Voight, BF, Volcik, KA, Waite, LL, Wong, A, Wu, Y, Zhang, W, Absher, D, Asiki, G, Barroso, I, Been, LF, Bolton, JL, Bonnycastle, LL, Brambilla, P, Burnett, MS, Cesana, G, Dimitriou, M, Doney, ASF, Döring, A, Elliott, P, Epstein, SE, Eyjolfsson, GIngi, Gigante, B, Goodarzi, MO, Grallert, H, Gravito, ML, Groves, CJ, Hallmans, G, Hartikainen, A-L, Hayward, C, Hernandez, D, Hicks, AA, Holm, H, Hung, Y-J, Illig, T, Jones, MR, Kaleebu, P, Kastelein, JJP, Khaw, K-T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimäki, T, Lin, S-Y, Lindström, J, Loos, RJF, Mach, F, McArdle, WL, Meisinger, C, Mitchell, BD, Müller, G, Nagaraja, R, Narisu, N, Nieminen, TVM, Nsubuga, RN, Olafsson, I, Ong, KK, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, DJ, Reilly, MP, Ridker, PM, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stančáková, A, Stirrups, K, Swift, AJ, Tiret, L, Uitterlinden, AG, L van Pelt, J, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, SH, Willemsen, G, Wilsgaard, T, Wilson, JF, Young, EH, Zhao, JHua, Adair, LS, Arveiler, D, Assimes, TL, Bandinelli, S, Bennett, F, Bochud, M, Boehm, BO, Boomsma, DI, Borecki, IB, Bornstein, SR, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, JC, Chen, Y-DIda, Collins, FS, Cooper, RS, Danesh, J, Dedoussis, G, de Faire, U, Feranil, AB, Ferrières, J, Ferrucci, L, Freimer, NB, Gieger, C, Groop, LC, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, TB, Hingorani, A, Hirschhorn, JN, Hofman, A, G Hovingh, K, Hsiung, CAgnes, Humphries, SE, Hunt, SC, Hveem, K, Iribarren, C, Jarvelin, M-R, Jula, A, Kähönen, M, Kaprio, J, Kesäniemi, A, Kivimaki, M, Kooner, JS, Koudstaal, PJ, Krauss, RM, Kuh, D, Kuusisto, J, Kyvik, KO, Laakso, M, Lakka, TA, Lind, L, Lindgren, CM, Martin, NG, März, W, McCarthy, MI, McKenzie, CA, Meneton, P, Metspalu, A, Moilanen, L, Morris, AD, Munroe, PB, Njølstad, I, Pedersen, NL, Power, C, Pramstaller, PP, Price, JF, Psaty, BM, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, DK, Saramies, J, Schwarz, PEH, Sheu, WH-H, Shuldiner, AR, Siegbahn, A, Spector, TD, Stefansson, K, Strachan, DP, Tayo, BO, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, CM, Vollenweider, P, Wallentin, L, Wareham, NJ, Whitfield, JB, Wolffenbuttel, BHR, Altshuler, D, Ordovas, JM, Boerwinkle, E, Palmer, CNA, Thorsteinsdottir, U, Chasman, DI, Rotter, JI, Franks, PW, Ripatti, S, L Cupples, A, Sandhu, MS, Rich, SS, Boehnke, M, Deloukas, P, Mohlke, KL, Ingelsson, E, Abecasis, GR, Daly, MJ, Neale, BM, Kathiresan, S
JournalNat Genet
Volume45
Issue11
Pages1345-52
Date Published2013 Nov
ISSN1546-1718
KeywordsBiological Transport, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors, Triglycerides
Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P

URLhttp://dx.doi.org/10.1038/ng.2795
DOI10.1038/ng.2795
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24097064?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID24097064
PubMed Central IDPMC3904346
Grant ListCZB/4/710 / / Chief Scientist Office / United Kingdom
CZB/4/672 / / Chief Scientist Office / United Kingdom
RG/08/008/25291 / / British Heart Foundation / United Kingdom
R01 HL107816 / HL / NHLBI NIH HHS / United States
R01 HL109946 / HL / NHLBI NIH HHS / United States
R01HL107816 / HL / NHLBI NIH HHS / United States
RG/08/014/24067 / / British Heart Foundation / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
MC_U950080926 / / Medical Research Council / United Kingdom
G1000143 / / Medical Research Council / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
MR/L003120/1 / / Medical Research Council / United Kingdom
R01 HL105756 / HL / NHLBI NIH HHS / United States
T32 HL007208 / HL / NHLBI NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada
MC_U123092720 / / Medical Research Council / United Kingdom
MC_U106179472 / / Medical Research Council / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
G0701863 / / Medical Research Council / United Kingdom
G0901213 / / Medical Research Council / United Kingdom
100891 / / Wellcome Trust / United Kingdom
090532 / / Wellcome Trust / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
PG/08/094/26019 / / British Heart Foundation / United Kingdom
T32HL007208 / HL / NHLBI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
G0801566 / / Medical Research Council / United Kingdom
MR/K013491/1 / / Medical Research Council / United Kingdom
MC_U106188470 / / Medical Research Council / United Kingdom
U01 HL069757 / HL / NHLBI NIH HHS / United States