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Sci Rep DOI:10.1038/srep02650

Comprehensive identification of mutational cancer driver genes across 12 tumor types.

Publication TypeJournal Article
Year of Publication2013
AuthorsTamborero, D, Gonzalez-Perez, A, Perez-Llamas, C, Deu-Pons, J, Kandoth, C, Reimand, J, Lawrence, MS, Getz, G, Bader, GD, Ding, L, López-Bigas, N
JournalSci Rep
Volume3
Pages2650
Date Published2013 Oct 02
ISSN2045-2322
KeywordsCarcinogens, Cell Transformation, Neoplastic, DNA Mutational Analysis, Gene Regulatory Networks, Genetic Association Studies, Genomics, Humans, Mutation, Neoplasms, Reproducibility of Results, Signal Transduction
Abstract

With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous molecular nature of the disease and the limitations of available computational methods. Here we show that the combination of complementary methods allows identifying a comprehensive and reliable list of cancer driver genes. We provide a list of 291 high-confidence cancer driver genes acting on 3,205 tumors from 12 different cancer types. Among those genes, some have not been previously identified as cancer drivers and 16 have clear preference to sustain mutations in one specific tumor type. The novel driver candidates complement our current picture of the emergence of these diseases. In summary, the catalog of driver genes and the methodology presented here open new avenues to better understand the mechanisms of tumorigenesis.

URLhttp://dx.doi.org/10.1038/srep02650
DOI10.1038/srep02650
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24084849?dopt=Abstract

Alternate JournalSci Rep
PubMed ID24084849
PubMed Central IDPMC3788361
Grant ListP41 GM103504 / GM / NIGMS NIH HHS / United States
U01 HG006517 / HG / NHGRI NIH HHS / United States
U54 HG003079 / HG / NHGRI NIH HHS / United States