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Diabetes, obesity & metabolism DOI:10.1111/dom.12158

Small-molecule inhibition of inflammatory β-cell death.

Publication TypeJournal Article
Year of Publication2013
AuthorsLundh, M, Scully, SS, Mandrup-Poulsen, T, Wagner, BK
JournalDiabetes, obesity & metabolism
Volume15 Suppl 3
Date Published2013/09/01

With the worldwide increase in diabetes prevalence there is a pressing unmet need for novel antidiabetic therapies. Insufficient insulin production due to impaired β-cell function and apoptotic reduction of β-cell mass is a common denominator in the pathogenesis of diabetes. Current treatments are directed at improving insulin sensitivity, and stimulating insulin secretion or replacing the hormone, but do not target progressive apoptotic β-cell loss. Here we review the current development of small-molecule inhibitors designed to rescue β-cells from apoptosis. Several distinct classes of small molecules have been identified that protect β-cells from inflammatory, oxidative and/or metabolically induced apoptosis. Although none of these have yet reached the clinic, β-cell protective small molecules alone or in combination with current therapies provide exciting opportunities for the development of novel treatments for diabetes.