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Gut DOI:10.1136/gutjnl-2012-303954

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.

Publication TypeJournal Article
Year of Publication2013
AuthorsKnights, D, Lassen, KG, Xavier, RJ
Date Published2013 Oct
KeywordsBacteria, Genetic Predisposition to Disease, Host-Pathogen Interactions, Humans, Inflammatory Bowel Diseases, Intestines, Microbiota, Phenotype, Signal Transduction

Studies of the genetics underlying inflammatory bowel diseases have increased our understanding of the pathways involved in both ulcerative colitis and Crohn's disease and focused attention on the role of the microbiome in these diseases. Full understanding of pathogenesis will require a comprehensive grasp of the delicate homeostasis between gut bacteria and the human host. In this review, we present current evidence of microbiome-gene interactions in the context of other known risk factors and mechanisms, and describe the next steps necessary to pair genetic variant and microbiome sequencing data from patient cohorts. We discuss the concept of dysbiosis, proposing that the functional composition of the gut microbiome may provide a more consistent definition of dysbiosis and may more readily provide evidence of genome-microbiome interactions in future exploratory studies.


Alternate JournalGut
PubMed ID24037875
PubMed Central IDPMC3822528
Grant ListR01 DK097485 / DK / NIDDK NIH HHS / United States
U01 DK062432 / DK / NIDDK NIH HHS / United States
DK062432 / DK / NIDDK NIH HHS / United States
DK097485 / DK / NIDDK NIH HHS / United States