A Central role for mTOR in lipid homeostasis.

Cell Metab
Authors
Dudley Lamming
David Sabatini
Keywords
Humans
Signal Transduction
TOR Serine-Threonine Kinases
Lipid Metabolism
Liver
Adipogenesis
Lipolysis
Adipose Tissue
Lipogenesis
Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis.
Year of Publication
2013
Journal
Cell Metab
Volume
18
Issue
4
Pages
465-9
Date Published
2013 Oct 01
ISSN
1932-7420
URL
http://linkinghub.elsevier.com/retrieve/pii/S1550-4131(13)00326-4
DOI
10.1016/j.cmet.2013.08.002
PubMed ID
23973332
PubMed Central ID
PMC3818790
Links
Grant list
K99/R00 AG041765 / AG / NIA NIH HHS / United States
R00 AG041765 / AG / NIA NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States
R01 GM072555 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States
R01 CA129105 / CA / NCI NIH HHS / United States
K99 AG041765 / AG / NIA NIH HHS / United States

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