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Cell Metab DOI:10.1016/j.cmet.2013.08.002

A Central role for mTOR in lipid homeostasis.

Publication TypeJournal Article
Year of Publication2013
AuthorsLamming, DW, Sabatini, DM
JournalCell Metab
Volume18
Issue4
Pages465-9
Date Published2013 Oct 01
ISSN1932-7420
KeywordsAdipogenesis, Adipose Tissue, Humans, Lipid Metabolism, Lipogenesis, Lipolysis, Liver, Signal Transduction, TOR Serine-Threonine Kinases
Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1550-4131(13)00326-4
DOI10.1016/j.cmet.2013.08.002
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23973332?dopt=Abstract

Alternate JournalCell Metab.
PubMed ID23973332
PubMed Central IDPMC3818790
Grant ListK99/R00 AG041765 / AG / NIA NIH HHS / United States
R00 AG041765 / AG / NIA NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States
R01 GM072555 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R01 CA129105 / CA / NCI NIH HHS / United States
K99 AG041765 / AG / NIA NIH HHS / United States