Scientific Publications

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.

Publication TypeJournal Article
AuthorsConway, KL, Kuballa P., Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M., Aldrich LN, Villablanca EJ, Peloquin JM, Goel G., Lee IA, Mizoguchi E., Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, and Xavier RJ
Abstract& Aims: Intestinal epithelial cells aid in mucosal defense by providing a physical barrier against entry of pathogenic bacteria and secreting anti-microbial peptides (AMPs). Autophagy is an important component of immune homeostasis. However, little is known about its role in specific cell types during bacterial infection in vivo. We investigated the role of autophagy in the response of intestinal epithelial and antigen-presenting cells to Salmonella infection in mice.
Year of Publication2013
JournalGastroenterology
Date Published (YYYY/MM/DD)2013/08/21
ISSN Number0016-5085
DOI10.1053/j.gastro.2013.08.035
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23973919?dopt=Abstract