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Gastroenterology DOI:10.1053/j.gastro.2013.08.035

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.

Publication TypeJournal Article
Year of Publication2013
AuthorsConway, KL, Kuballa, P, Song, JH, Patel, KK, Castoreno, AB, Yilmaz, OH, Jijon, HB, Zhang, M, Aldrich, LN, Villablanca, EJ, Peloquin, JM, Goel, G, Lee, IA, Mizoguchi, E, Shi, HN, Bhan, AK, Shaw, SY, Schreiber, SL, Virgin, HW, Shamji, AF, Stappenbeck, TS, Reinecker, HC, Xavier, RJ
Date Published2013/08/21

& Aims: Intestinal epithelial cells aid in mucosal defense by providing a physical barrier against entry of pathogenic bacteria and secreting anti-microbial peptides (AMPs). Autophagy is an important component of immune homeostasis. However, little is known about its role in specific cell types during bacterial infection in vivo. We investigated the role of autophagy in the response of intestinal epithelial and antigen-presenting cells to Salmonella infection in mice.


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