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Lung Cancer Manag DOI:10.2217/lmt.12.40

Targeted therapy for squamous cell lung cancer.

Publication TypeJournal Article
Year of Publication2012
AuthorsLiao, RG, Watanabe, H, Meyerson, M, Hammerman, PS
JournalLung Cancer Manag
Date Published2012 Dec

Lung squamous cell carcinoma (SqCC) is the second most common subtype of non-small-cell lung cancer and leads to 40,000-50,000 deaths per year in the USA. Management of non-small-cell lung cancer has dramatically changed over the past decade with the introduction of targeted therapeutic agents for genotypically selected individuals with lung adenocarcinoma. These agents lead to improved outcomes, and it has now become the standard of care to perform routine molecular genotyping of lung adenocarcinomas. By contrast, progress in lung SqCC has been modest, and there has yet to be a successful demonstration of targeted therapy in this disease. Here, we review exciting work from ongoing genomic characterization and biomarker validation efforts that have nominated several likely therapeutic targets in lung SqCCs. These studies suggest that targeted therapies are likely to be successful in the treatment of lung SqCCs and should be further explored in both preclinical models and in clinical trials.


Alternate JournalLung Cancer Manag
PubMed ID23956794
PubMed Central IDPMC3744181
Grant ListK08 CA163677 / CA / NCI NIH HHS / United States