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Am J Hum Genet DOI:10.1016/j.ajhg.2013.07.006

Genetic evidence for recent population mixture in India.

Publication TypeJournal Article
Year of Publication2013
AuthorsMoorjani, P, Thangaraj, K, Patterson, N, Lipson, M, Loh, P-R, Govindaraj, P, Berger, B, Reich, D, Singh, L
JournalAm J Hum Genet
Volume93
Issue3
Pages422-38
Date Published2013 Sep 05
ISSN1537-6605
KeywordsEuropean Continental Ancestry Group, Gene Pool, Genetics, Population, Geography, Humans, India, Linguistics, Linkage Disequilibrium, Models, Genetic, Principal Component Analysis, Time Factors
Abstract

Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian history. We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0002-9297(13)00324-8
DOI10.1016/j.ajhg.2013.07.006
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23932107?dopt=Abstract

Alternate JournalAm. J. Hum. Genet.
PubMed ID23932107
PubMed Central IDPMC3769933
Grant ListR01 GM100233 / GM / NIGMS NIH HHS / United States
R01 HG006399 / HG / NHGRI NIH HHS / United States
GM100233 / GM / NIGMS NIH HHS / United States