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Psychoneuroendocrinology DOI:10.1016/j.psyneuen.2017.12.007

Traumatic stress and accelerated DNA methylation age: A meta-analysis.

Publication TypeJournal Article
Year of Publication2018
AuthorsWolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPF, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM, Logue, MW
JournalPsychoneuroendocrinology
Volume92
Pages123-134
Date Published2018 06
ISSN1873-3360
KeywordsAdult, Cohort Studies, DNA Methylation, Epigenesis, Genetic, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Stress Disorders, Post-Traumatic, Trauma Severity Indices
Abstract

BACKGROUND: Recent studies examining the association between posttraumatic stress disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of cellular age that exceed chronological age, have yielded mixed results.

METHODS: We conducted a meta-analysis of trauma exposure and PTSD diagnosis and symptom severity in association with accelerated DNA methylation age using data from 9 cohorts contributing to the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (combined N = 2186). Associations between demographic and cellular variables and accelerated DNA methylation age were also examined, as was the moderating influence of demographic variables.

RESULTS: Meta-analysis of regression coefficients from contributing cohorts revealed that childhood trauma exposure (when measured with the Childhood Trauma Questionnaire) and lifetime PTSD severity evidenced significant, albeit small, meta-analytic associations with accelerated DNA methylation age (ps = 0.028 and 0.016, respectively). Sex, CD4T cell proportions, and natural killer cell proportions were also significantly associated with accelerated DNA methylation age (all ps 

CONCLUSIONS: Results suggest that traumatic stress is associated with advanced epigenetic age and raise the possibility that cells integral to immune system maintenance and responsivity play a role in this. This study highlights the need for additional research into the biological mechanisms linking traumatic stress to accelerated DNA methylation age and the importance of furthering our understanding of the neurobiological and health consequences of PTSD.

DOI10.1016/j.psyneuen.2017.12.007
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29452766?dopt=Abstract

Alternate JournalPsychoneuroendocrinology
PubMed ID29452766
PubMed Central IDPMC5924645
Grant ListR03 AG051877 / AG / NIA NIH HHS / United States
U01 MH087981 / MH / NIMH NIH HHS / United States
R56 MH071537 / MH / NIMH NIH HHS / United States
R01 DA022720 / DA / NIDA NIH HHS / United States
R01 MH071537 / MH / NIMH NIH HHS / United States
R01 AI129788 / AI / NIAID NIH HHS / United States
R01 MH096764 / MH / NIMH NIH HHS / United States
RC1 MH088283 / MH / NIMH NIH HHS / United States
R01 MH108641 / MH / NIMH NIH HHS / United States
R01 MH093500 / MH / NIMH NIH HHS / United States
I01 BX002577 / BX / BLRD VA / United States
I01 BX002150 / BX / BLRD VA / United States
U01 MH109536 / MH / NIMH NIH HHS / United States
R01 MH105379 / MH / NIMH NIH HHS / United States
I01 CX000431 / CX / CSRD VA / United States
I01 CX001276 / CX / CSRD VA / United States
R01 MH106595 / MH / NIMH NIH HHS / United States
R01 MH108826 / MH / NIMH NIH HHS / United States
P2C HD050924 / HD / NICHD NIH HHS / United States
IK2 CX000525 / CX / CSRD VA / United States
R01 MH079806 / MH / NIMH NIH HHS / United States
R21 MH102834 / MH / NIMH NIH HHS / United States