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Nat Genet DOI:10.1038/s41588-018-0099-7

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.

Publication TypeJournal Article
Year of Publication2018
AuthorsVerbanck, M, Chen, C-Y, Neale, B, Do, R
JournalNat Genet
Volume50
Issue5
Pages693-698
Date Published2018 05
ISSN1546-1718
KeywordsDisease, Genetic Pleiotropy, Genetic Predisposition to Disease, Genetic Variation, Humans
Abstract

Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on the exposure in Mendelian randomization (MR). Violation of the 'no horizontal pleiotropy' assumption can cause severe bias in MR. We developed the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test to identify horizontal pleiotropic outliers in multi-instrument summary-level MR testing. We showed using simulations that the MR-PRESSO test is best suited when horizontal pleiotropy occurs in 

DOI10.1038/s41588-018-0099-7
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29686387?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID29686387
PubMed Central IDPMC6083837
Grant ListR01 MH094469 / MH / NIMH NIH HHS / United States
R35 GM124836 / GM / NIGMS NIH HHS / United States
R01 HL139865 / HL / NHLBI NIH HHS / United States
R01 MH107649 / MH / NIMH NIH HHS / United States
U01 HG009088 / HG / NHGRI NIH HHS / United States