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Transl Psychiatry DOI:10.1038/s41398-018-0229-0

Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis.

Publication TypeJournal Article
Year of Publication2018
AuthorsVelthorst, E, Froudist-Walsh, S, Stahl, E, Ruderfer, D, Ivanov, I, Buxbaum, J, Banaschewski, T, Bokde, ALW, Dipl-Psych, UBromberg, Büchel, C, Quinlan, EBurke, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, M-LPaillère, Artiges, E, Nees, F, Orfanos, DPapadopoul, Paus, T, Poustka, L, Hohmann, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Reichenberg, A
Corporate AuthorsiPSYCH-Broad ASD Group, the IMAGEN consortium
JournalTransl Psychiatry
Date Published2018 09 26
KeywordsAdolescent, Autism Spectrum Disorder, Brain, Female, Genetic Predisposition to Disease, Humans, Male, Multifactorial Inheritance, Psychotic Disorders, Risk Factors, Schizophrenia, Schizophrenic Psychology, Social Behavior

While psychotic experiences (PEs) are assumed to represent psychosis liability, general population studies have not been able to establish significant associations between polygenic risk scores (PRS) and PEs. Previous work suggests that PEs may only represent significant risk when accompanied by social impairment. Leveraging data from the large longitudinal IMAGEN cohort, including 2096 14-year old adolescents that were followed-up to age 18, we tested whether the association between polygenic risk and PEs is mediated by (increasing) impairments in social functioning and social cognitive processes. Using structural equation modeling (SEM) for the subset of participants (n = 643) with complete baseline and follow-up data, we examined pathways to PEs. We found that high polygenic risk for schizophrenia (p = 0.014), reduced brain activity to emotional stimuli (p = 0.009) and social impairments in late adolescence (p 


Alternate JournalTransl Psychiatry
PubMed ID30258131
PubMed Central IDPMC6158250
Grant ListMR/N000390/1 / / Medical Research Council / United Kingdom
R01 MH085772 / MH / NIMH NIH HHS / United States
U54 EB020403 / EB / NIBIB NIH HHS / United States
MR/N027558/1 / / Medical Research Council / United Kingdom
/ / Department of Health / United Kingdom