You are here

Epigenomics DOI:10.2217/epi-2018-0049

Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.

Publication TypeJournal Article
Year of Publication2018
AuthorsUddin, M, Ratanatharathorn, A, Armstrong, D, Kuan, P-F, Aiello, AE, Bromet, EJ, Galea, S, Koenen, KC, Luft, B, Ressler, KJ, Wildman, DE, Nievergelt, CM, Smith, A
JournalEpigenomics
Volume10
Issue12
Pages1585-1601
Date Published2018 Dec
ISSN1750-192X
Abstract

AIM: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.

MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.

RESULTS: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).

CONCLUSION: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.

DOI10.2217/epi-2018-0049
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/30456986?dopt=Abstract

Alternate JournalEpigenomics
PubMed ID30456986
PubMed Central IDPMC6331697
Grant ListP2C HD050924 / HD / NICHD NIH HHS / United States
R01 MH108826 / MH / NIMH NIH HHS / United States
U01 OH011478 / OH / NIOSH CDC HHS / United States
R01 DA022720 / DA / NIDA NIH HHS / United States
RC1 MH088283 / MH / NIMH NIH HHS / United States
U01 OH010718 / OH / NIOSH CDC HHS / United States
U01 OH010416 / OH / NIOSH CDC HHS / United States