|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Uddin, M, Ratanatharathorn, A, Armstrong, D, Kuan, P-F, Aiello, AE, Bromet, EJ, Galea, S, Koenen, KC, Luft, B, Ressler, KJ, Wildman, DE, Nievergelt, CM, Smith, A|
|Date Published||2018 Dec|
AIM: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.
MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.
RESULTS: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).
CONCLUSION: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.
|PubMed Central ID||PMC6331697|
|Grant List||P2C HD050924 / HD / NICHD NIH HHS / United States |
R01 MH108826 / MH / NIMH NIH HHS / United States
U01 OH011478 / OH / NIOSH CDC HHS / United States
R01 DA022720 / DA / NIDA NIH HHS / United States
RC1 MH088283 / MH / NIMH NIH HHS / United States
U01 OH010718 / OH / NIOSH CDC HHS / United States
U01 OH010416 / OH / NIOSH CDC HHS / United States