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Epigenomics DOI:10.2217/epi-2018-0049

Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.

Publication TypeJournal Article
Year of Publication2018
AuthorsUddin, M, Ratanatharathorn, A, Armstrong, D, Kuan, P-F, Aiello, AE, Bromet, EJ, Galea, S, Koenen, KC, Luft, B, Ressler, KJ, Wildman, DE, Nievergelt, CM, Smith, A
Date Published2018 Dec
KeywordsAdult, Aged, Biomarkers, Cohort Studies, Demography, DNA Methylation, Endosomal Sorting Complexes Required for Transport, Epigenomics, Female, Genomics, Humans, Male, Middle Aged, Neuregulin-1, Phosphoproteins, Stress Disorders, Post-Traumatic

AIM: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.RESULTS: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).CONCLUSION: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.


Alternate JournalEpigenomics
PubMed ID30456986
PubMed Central IDPMC6331697
Grant ListR56 MH071537 / MH / NIMH NIH HHS / United States
R01 DA022720 / DA / NIDA NIH HHS / United States
R01 MH071537 / MH / NIMH NIH HHS / United States
U01 OH010718 / OH / NIOSH CDC HHS / United States
R01 MH096764 / MH / NIMH NIH HHS / United States
U01OH011478 / ACL / ACL HHS / United States
R01 MH106595 / MH / NIMH NIH HHS / United States
U01 OH011478 / OH / NIOSH CDC HHS / United States
RC1 MH088283 / MH / NIMH NIH HHS / United States
U01 OH010416 / OH / NIOSH CDC HHS / United States
R01 MH108826 / MH / NIMH NIH HHS / United States
P2C HD050924 / HD / NICHD NIH HHS / United States