Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.

J Clin Oncol
Authors
Keywords
Abstract

PURPOSE: Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles.

PATIENTS AND METHODS: We determined subgroup affiliation, TP53 mutation status, and clinical outcome in a discovery cohort of 397 medulloblastomas. We subsequently validated our results on an independent cohort of 156 medulloblastomas.

RESULTS: TP53 mutations are enriched in wingless (WNT; 16%) and sonic hedgehog (SHH; 21%) medulloblastomas and are virtually absent in subgroups 3 and 4 tumors (P

CONCLUSION: Subgroup-specific analysis reconciles prior conflicting publications and confirms that TP53 mutations are enriched among SHH medulloblastomas, in which they portend poor outcome and account for a large proportion of treatment failures in these patients.

Year of Publication
2013
Journal
J Clin Oncol
Volume
31
Issue
23
Pages
2927-35
Date Published
2013 Aug 10
ISSN
1527-7755
URL
DOI
10.1200/JCO.2012.48.5052
PubMed ID
23835706
PubMed Central ID
PMC4878050
Links
Grant list
P30 HD018655 / HD / NICHD NIH HHS / United States
R01 CA109467 / CA / NCI NIH HHS / United States
Cancer Research UK / United Kingdom