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Cell Rep DOI:10.1016/j.celrep.2018.01.007

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.

Publication TypeJournal Article
Year of Publication2018
AuthorsPriya, R, Paredes, MFrancisca, Karayannis, T, Yusuf, N, Liu, X, Jaglin, X, Graef, I, Alvarez-Buylla, A, Fishell, G
JournalCell Rep
Volume22
Issue7
Pages1695-1709
Date Published2018 02 13
ISSN2211-1247
Abstract

We demonstrate that cortical interneurons derived from ventral eminences, including the caudal ganglionic eminence, undergo programmed cell death. Moreover, with the exception of VIP interneurons, this occurs in a manner that is activity-dependent. In addition, we demonstrate that, within interneurons, Calcineurin, a calcium-dependent protein phosphatase, plays a critical role in sequentially linking activity to maturation (E15-P5) and survival (P5-P20). Specifically, embryonic inactivation of Calcineurin results in a failure of interneurons to morphologically mature and prevents them from undergoing apoptosis. By contrast, early postnatal inactivation of Calcineurin increases apoptosis. We conclude that Calcineurin serves a dual role of promoting first the differentiation of interneurons and, subsequently, their survival.

DOI10.1016/j.celrep.2018.01.007
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29444424?dopt=Abstract

Alternate JournalCell Rep
PubMed ID29444424
PubMed Central IDPMC6215776
Grant ListP01 NS074972 / NS / NINDS NIH HHS / United States
R01 MH071679 / MH / NIMH NIH HHS / United States
K08 NS091537 / NS / NINDS NIH HHS / United States
R01 EY025174 / EY / NEI NIH HHS / United States
R01 NS081297 / NS / NINDS NIH HHS / United States