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Cell Rep DOI:10.1016/j.celrep.2018.01.007

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.

Publication TypeJournal Article
Year of Publication2018
AuthorsPriya, R, Paredes, MFrancisca, Karayannis, T, Yusuf, N, Liu, X, Jaglin, X, Graef, I, Alvarez-Buylla, A, Fishell, G
JournalCell Rep
Date Published2018 02 13
KeywordsAnimals, bcl-2-Associated X Protein, Calcineurin, Calcium, Cell Count, Cell Death, Cell Survival, Cerebral Cortex, Embryo, Mammalian, Interneurons, Median Eminence, Mice, Neuroglia, Signal Transduction, Solubility, Time Factors

We demonstrate that cortical interneurons derived from ventral eminences, including the caudal ganglionic eminence, undergo programmed cell death. Moreover, with the exception of VIP interneurons, this occurs in a manner that is activity-dependent. In addition, we demonstrate that, within interneurons, Calcineurin, a calcium-dependent protein phosphatase, plays a critical role in sequentially linking activity to maturation (E15-P5) and survival (P5-P20). Specifically, embryonic inactivation of Calcineurin results in a failure of interneurons to morphologically mature and prevents them from undergoing apoptosis. By contrast, early postnatal inactivation of Calcineurin increases apoptosis. We conclude that Calcineurin serves a dual role of promoting first the differentiation of interneurons and, subsequently, their survival.


Alternate JournalCell Rep
PubMed ID29444424
PubMed Central IDPMC6215776
Grant ListP01 NS074972 / NS / NINDS NIH HHS / United States
R01 MH071679 / MH / NIMH NIH HHS / United States
K08 NS091537 / NS / NINDS NIH HHS / United States
R01 EY025174 / EY / NEI NIH HHS / United States
R01 NS081297 / NS / NINDS NIH HHS / United States