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Cell DOI:10.1016/j.cell.2018.04.019

The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection.

Publication TypeJournal Article
Year of Publication2018
AuthorsMarkowitz, JE, Gillis, WF, Beron, CC, Neufeld, SQ, Robertson, K, Bhagat, ND, Peterson, RE, Peterson, E, Hyun, M, Linderman, SW, Sabatini, BL, Datta, SRobert
Date Published2018 06 28
KeywordsAnimals, Behavior, Animal, Calcium, Corpus Striatum, Electrodes, Implanted, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, N-Methylaspartate, Neurons, Photometry, Receptors, Dopamine D1

Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural activity in the direct and indirect pathways of dorsolateral striatum (DLS) as mice spontaneously express action sequences. These experiments reveal that DLS neurons systematically encode information about the identity and ordering of sub-second 3D behavioral motifs; this encoding is facilitated by fast-timescale decorrelations between the direct and indirect pathways. Furthermore, lesioning the DLS prevents appropriate sequence assembly during exploratory or odor-evoked behaviors. By characterizing naturalistic behavior at neural timescales, these experiments identify a code for elemental 3D pose dynamics built from complementary pathway dynamics, support a role for DLS in constructing meaningful behavioral sequences, and suggest models for how actions are sculpted over time.


Alternate JournalCell
PubMed ID29779950
PubMed Central IDPMC6026065
Grant ListU01 NS094190 / NS / NINDS NIH HHS / United States
R01 DC016222 / DC / NIDCD NIH HHS / United States
R01 DC011558 / DC / NIDCD NIH HHS / United States
P30 HD018655 / HD / NICHD NIH HHS / United States
P30 EY012196 / EY / NEI NIH HHS / United States
U01 NS094191 / NS / NINDS NIH HHS / United States