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Development DOI:10.1242/dev.154583

Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon.

Publication TypeJournal Article
Year of Publication2018
AuthorsGodbole, G, Shetty, AS, Roy, A, D'Souza, L, Chen, B, Miyoshi, G, Fishell, G, Tole, S
Date Published2018 01 09
KeywordsAnimals, Forkhead Transcription Factors, Gene Expression Regulation, Developmental, Hippocampus, LIM-Homeodomain Proteins, Mice, Mice, Transgenic, Nerve Tissue Proteins, Telencephalon, Transcription Factors

During forebrain development, a telencephalic organizer called the cortical hem is crucial for inducing hippocampal fate in adjacent cortical neuroepithelium. How the hem is restricted to its medial position is therefore a fundamental patterning issue. Here, we demonstrate that - interactions are crucial for the formation of the hem. Loss of either gene causes a region of the cortical neuroepithelium to transform into hem. We show that FOXG1 regulates expression in the cortical primordium. In the absence of , the presence of is sufficient to suppress hem fate, and hippocampal markers appear selectively in -expressing regions. FOXG1 also restricts the temporal window in which loss of results in a transformation of cortical primordium into hem. Therefore, and form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer.


Alternate JournalDevelopment
PubMed ID29229772
PubMed Central IDPMC5825872
Grant ListP01 NS074972 / NS / NINDS NIH HHS / United States
R01 NS089777 / NS / NINDS NIH HHS / United States
IA/E/11/1/500402 / / Wellcome Trust-DBT India Alliance / India
R01 MH094589 / MH / NIMH NIH HHS / United States
R01 MH095147 / MH / NIMH NIH HHS / United States
/ / Wellcome Trust / United Kingdom
R01 NS081297 / NS / NINDS NIH HHS / United States