Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon.
During forebrain development, a telencephalic organizer called the cortical hem is crucial for inducing hippocampal fate in adjacent cortical neuroepithelium. How the hem is restricted to its medial position is therefore a fundamental patterning issue. Here, we demonstrate that - interactions are crucial for the formation of the hem. Loss of either gene causes a region of the cortical neuroepithelium to transform into hem. We show that FOXG1 regulates expression in the cortical primordium. In the absence of , the presence of is sufficient to suppress hem fate, and hippocampal markers appear selectively in -expressing regions. FOXG1 also restricts the temporal window in which loss of results in a transformation of cortical primordium into hem. Therefore, and form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer.
|Year of Publication
2018 01 09
|PubMed Central ID
P01 NS074972 / NS / NINDS NIH HHS / United States
R01 NS089777 / NS / NINDS NIH HHS / United States
IA/E/11/1/500402 / Wellcome Trust-DBT India Alliance / India
R01 MH094589 / MH / NIMH NIH HHS / United States
R01 MH095147 / MH / NIMH NIH HHS / United States
Wellcome Trust / United Kingdom
R01 NS081297 / NS / NINDS NIH HHS / United States