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Cell Stem Cell DOI:10.1016/j.stem.2018.05.019

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.

Publication TypeJournal Article
Year of Publication2018
AuthorsGibbs, RM, Lipnick, S, Bateman, JW, Chen, L, Cousins, HC, Hubbard, EG, Jowett, G, LaPointe, DS, McGredy, MJ, Odonkor, MN, Repetti, G, Thomas, E, Rubin, LL
JournalCell Stem Cell
Volume23
Issue1
Pages21-24
Date Published2018 Jul 05
ISSN1875-9777
Abstract

The genetic complexity, clinical variability, and inaccessibility of affected tissue in neurodegenerative and neuropsychiatric disorders have largely prevented the development of effective disease-modifying therapeutics. A precision medicine approach that integrates genomics, deep clinical phenotyping, and patient stem cell models may facilitate identification of underlying biological drivers and targeted drug development.

DOI10.1016/j.stem.2018.05.019
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29887317?dopt=Abstract

Alternate JournalCell Stem Cell
PubMed ID29887317