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Curr Top Dev Biol DOI:10.1016/bs.ctdb.2018.03.002

Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease.

Publication TypeJournal Article
Year of Publication2018
AuthorsBrown, J, Quadrato, G, Arlotta, P
JournalCurr Top Dev Biol
Volume129
Pages99-122
Date Published2018
ISSN1557-8933
Abstract

The study of the cellular and molecular processes of the developing human brain has been hindered by access to suitable models of living human brain tissue. Recently developed 3D cell culture models offer the promise of studying fundamental brain processes in the context of human genetic background and species-specific developmental mechanisms. Here, we review the current state of 3D human brain organoid models and consider their potential to enable investigation of complex aspects of human brain development and the underpinning of human neurological disease.

DOI10.1016/bs.ctdb.2018.03.002
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29801532?dopt=Abstract

Alternate JournalCurr. Top. Dev. Biol.
PubMed ID29801532