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Med Dosim DOI:10.1016/j.meddos.2013.05.002

Circumferential or sectored beam arrangements for stereotactic body radiation therapy (SBRT) of primary lung tumors: effect on target and normal-structure dose-volume metrics.

Publication TypeJournal Article
Year of Publication2013
AuthorsRosenberg, MW, Kato, CM, Carson, KMP, Matsunaga, NM, Arao, RF, Doss, EJ, McCracken, CL, Meng, LZ, Chen, Y, Laub, WU, Fuss, M, Tanyi, JA
JournalMed Dosim
Volume38
Issue4
Pages407-12
Date Published2013 Winter
ISSN1873-4022
KeywordsAged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Female, Humans, Lung Neoplasms, Male, Middle Aged, Radiosurgery, Radiotherapy Planning, Computer-Assisted, Radiotherapy, Intensity-Modulated
Abstract

To compare 2 beam arrangements, sectored (beam entry over ipsilateral hemithorax) vs circumferential (beam entry over both ipsilateral and contralateral lungs), for static-gantry intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques with respect to target and organs-at-risk (OAR) dose-volume metrics, as well as treatment delivery efficiency. Data from 60 consecutive patients treated using stereotactic body radiation therapy (SBRT) for primary non-small-cell lung cancer (NSCLC) formed the basis of this study. Four treatment plans were generated per data set: IMRT/VMAT plans using sectored (-s) and circumferential (-c) configurations. The prescribed dose (PD) was 60Gy in 5 fractions to 95% of the planning target volume (PTV) (maximum PTV dose ~ 150% PD) for a 6-MV photon beam. Plan conformality, R50 (ratio of volume circumscribed by the 50% isodose line and the PTV), and D2cm (Dmax at a distance ≥2cm beyond the PTV) were evaluated. For lungs, mean doses (mean lung dose [MLD]) and percent V30/V20/V10/V5Gy were assessed. Spinal cord and esophagus Dmax and D5/D50 were computed. Chest wall (CW) Dmax and absolute V30/V20/V10/V5Gy were reported. Sectored SBRT planning resulted in significant decrease in contralateral MLD and V10/V5Gy, as well as contralateral CW Dmax and V10/V5Gy (all p

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0958-3947(13)00063-0
DOI10.1016/j.meddos.2013.05.002
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23810414?dopt=Abstract

Alternate JournalMed Dosim
PubMed ID23810414