Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
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Abstract | Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88) presented a critique of our recently published paper in Cell Reports entitled 'Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets' (Lam et al., Cell Reports, Vol. 21, 2017, 2597-2613). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, 2018, 229-237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from 'inflation in the FDR [false discovery rate]', as suggested by Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88), and are not 'more relevant to the genetic contributions to education than they are to the genetic contributions to intelligence'. |
Year of Publication | 2018
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Journal | Twin Res Hum Genet
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Volume | 21
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Issue | 5
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Pages | 394-397
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Date Published | 2018 10
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ISSN | 1832-4274
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DOI | 10.1017/thg.2018.46
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PubMed ID | 30001766
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Grant list | G0100594 / Medical Research Council / United Kingdom
G0600237 / Medical Research Council / United Kingdom
G0901461 / Medical Research Council / United Kingdom
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