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Psychol Med DOI:10.1017/S0033291718003495

Posttraumatic stress disorder and incidence of thyroid dysfunction in women.

Publication TypeJournal Article
Year of Publication2018
AuthorsJung, SJae, Kang, JH, Roberts, AL, Nishimi, K, Chen, Q, Sumner, JA, Kubzansky, L, Koenen, KC
JournalPsychol Med
Date Published2018 Nov 29

BACKGROUND: Abnormal thyroid function is prevalent among women and has been linked to increased risk of chronic disease. Posttraumatic stress disorder (PTSD) has been linked to thyroid dysfunction in some studies; however, the results have been inconsistent. Thus, we evaluated trauma exposure and PTSD symptoms in relation to incident thyroid dysfunction in a large longitudinal cohort of civilian women.

METHODS: We used data from 45 992 women from the ongoing Nurses' Health Study II, a longitudinal US cohort study that began in 1989. In 2008, history of trauma and PTSD were assessed with the Short Screening Scale for Diagnostic and Statistical Manual of Mental Disorders, fourth edition, PTSD, and incident thyroid dysfunction was determined by participants' self-report in biennial questionnaires of physician-diagnosed hypothyroidism and Graves' hyperthyroidism. The study period was from 1989 to 2013. Proportional hazard models were used to estimate multivariable-adjusted hazard ratios and 95% confidence intervals (CIs) for incident hypothyroidism and Graves' hyperthyroidism.

RESULTS: In multivariable-adjusted models, we found significant associations for PTSD only with hypothyroidism [p-trend

CONCLUSIONS: PTSD was associated with higher risk of hypothyroidism in a dose-dependent fashion. Highlighted awareness for thyroid dysfunction may be especially important in women with PTSD.


Alternate JournalPsychol Med
PubMed ID30488818