|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Christian, S, Merz, C, Evans, L, Gradl, S, Seidel, H, Friberg, A, Eheim, A, Lejeune, P, Brzezinka, K, Zimmermann, K, Ferrara, S, Meyer, H, Lesche, R, Stoeckigt, D, Bauser, M, Haegebarth, A, Sykes, DB, Scadden, DT, Losman, J-A, Janzer, A|
|Date Published||2019 10|
|Keywords||Animals, Antineoplastic Agents, Apoptosis, Cell Differentiation, Cell Line, Tumor, Enzyme Inhibitors, Female, HL-60 Cells, Humans, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Mice, Mice, Inbred NOD, Mice, SCID, Oxidoreductases Acting on CH-CH Group Donors, Pyrimidines, THP-1 Cells, Translocation, Genetic|
Acute myeloid leukemia (AML) is a devastating disease, with the majority of patients dying within a year of diagnosis. For patients with relapsed/refractory AML, the prognosis is particularly poor with currently available treatments. Although genetically heterogeneous, AML subtypes share a common differentiation arrest at hematopoietic progenitor stages. Overcoming this differentiation arrest has the potential to improve the long-term survival of patients, as is the case in acute promyelocytic leukemia (APL), which is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. Treatment of APL with all-trans retinoic acid (ATRA) induces terminal differentiation and apoptosis of leukemic promyelocytes, resulting in cure rates of over 80%. Unfortunately, similarly efficacious differentiation therapies have, to date, been lacking outside of APL. Inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine synthesis pathway, was recently reported to induce differentiation of diverse AML subtypes. In this report we describe the discovery and characterization of BAY 2402234 - a novel, potent, selective and orally bioavailable DHODH inhibitor that shows monotherapy efficacy and differentiation induction across multiple AML subtypes. Herein, we present the preclinical data that led to initiation of a phase I evaluation of this inhibitor in myeloid malignancies.