Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Schnabel, RB, Yin, X, Larson, MG, Yamamoto, JF, Fontes, JD, Kathiresan, S, Rong, J, Levy, D, Keaney, JF, Wang, TJ, Murabito, JM, Vasan, RS, Benjamin, EJ |
Journal | Arterioscler Thromb Vasc Biol |
Volume | 33 |
Issue | 7 |
Pages | 1728-33 |
Date Published | 2013 Jul |
ISSN | 1524-4636 |
Keywords | Aged, Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Disease-Free Survival, Female, Health Surveys, Humans, Incidence, Inflammation, Inflammation Mediators, Intercellular Adhesion Molecule-1, Interleukin-6, Male, Massachusetts, Middle Aged, Multivariate Analysis, Principal Component Analysis, Prognosis, Proportional Hazards Models, Receptors, Tumor Necrosis Factor, Type II, Risk Assessment, Risk Factors, Time Factors |
Abstract | OBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality. APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD. |
URL | http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=23640499 |
DOI | 10.1161/ATVBAHA.112.301174 |
Pubmed | |
Alternate Journal | Arterioscler. Thromb. Vasc. Biol. |
PubMed ID | 23640499 |
PubMed Central ID | PMC3753537 |
Grant List | R01 HL071039 / HL / NHLBI NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States R01 HL064753 / HL / NHLBI NIH HHS / United States N01 HC025195 / HC / NHLBI NIH HHS / United States R01 HL076784 / HL / NHLBI NIH HHS / United States K23 HL083102 / HL / NHLBI NIH HHS / United States K24 HL004334 / HL / NHLBI NIH HHS / United States K24 HL004334-01A1 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R01 AG028321 / AG / NIA NIH HHS / United States |
Arterioscler Thromb Vasc Biol DOI:10.1161/ATVBAHA.112.301174
Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community.
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