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Arterioscler Thromb Vasc Biol DOI:10.1161/ATVBAHA.112.301174

Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community.

Publication TypeJournal Article
Year of Publication2013
AuthorsSchnabel, RB, Yin, X, Larson, MG, Yamamoto, JF, Fontes, JD, Kathiresan, S, Rong, J, Levy, D, Keaney, JF, Wang, TJ, Murabito, JM, Vasan, RS, Benjamin, EJ
JournalArterioscler Thromb Vasc Biol
Volume33
Issue7
Pages1728-33
Date Published2013 Jul
ISSN1524-4636
KeywordsAged, Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Disease-Free Survival, Female, Health Surveys, Humans, Incidence, Inflammation, Inflammation Mediators, Intercellular Adhesion Molecule-1, Interleukin-6, Male, Massachusetts, Middle Aged, Multivariate Analysis, Principal Component Analysis, Prognosis, Proportional Hazards Models, Receptors, Tumor Necrosis Factor, Type II, Risk Assessment, Risk Factors, Time Factors
Abstract

OBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.

APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P

CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD.

URLhttp://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=23640499
DOI10.1161/ATVBAHA.112.301174
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23640499?dopt=Abstract

Alternate JournalArterioscler. Thromb. Vasc. Biol.
PubMed ID23640499
PubMed Central IDPMC3753537
Grant ListR01 HL071039 / HL / NHLBI NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
R01 HL064753 / HL / NHLBI NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
R01 HL076784 / HL / NHLBI NIH HHS / United States
K23 HL083102 / HL / NHLBI NIH HHS / United States
K24 HL004334 / HL / NHLBI NIH HHS / United States
K24 HL004334-01A1 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
R01 AG028321 / AG / NIA NIH HHS / United States