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Nat Genet DOI:10.1038/ng.2653

The Genotype-Tissue Expression (GTEx) project.

Publication TypeJournal Article
Year of Publication2013
Corporate AuthorsGTEx Consortium
JournalNat Genet
Volume45
Issue6
Pages580-5
Date Published2013 Jun
ISSN1546-1718
KeywordsConsensus Development Conferences, NIH as Topic, Gene Expression, Gene Expression Profiling, Genome-Wide Association Study, Government Programs, Humans, Molecular Sequence Annotation, Organ Specificity, Quantitative Trait Loci, Tissue Banks, United States
Abstract

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.

URLhttp://dx.doi.org/10.1038/ng.2653
DOI10.1038/ng.2653
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23715323?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID23715323
PubMed Central IDPMC4010069
Grant ListR01 DA006227-17 / DA / NIDA NIH HHS / United States
R01 DA006227 / DA / NIDA NIH HHS / United States
R01 MH101819 / MH / NIMH NIH HHS / United States
R01 DA033684 / DA / NIDA NIH HHS / United States
R01 MH090936 / MH / NIMH NIH HHS / United States
Z99 HG999999 / / Intramural NIH HHS / United States
090532 / / Wellcome Trust / United Kingdom
HHSN261200800001E / / PHS HHS / United States
R01 MH090951 / MH / NIMH NIH HHS / United States
HHSN268201000029C / / PHS HHS / United States
R01 MH090948 / MH / NIMH NIH HHS / United States
R01 MH090941 / MH / NIMH NIH HHS / United States
HHSN261200800001C / RC / CCR NIH HHS / United States
R01 MH090937 / MH / NIMH NIH HHS / United States
HHSN268201000029C / HL / NHLBI NIH HHS / United States
HHSN261200800001E / CA / NCI NIH HHS / United States