CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.
Nat Neurosci
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Abstract | In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia. |
Year of Publication | 2013
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Journal | Nat Neurosci
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Volume | 16
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Issue | 7
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Pages | 848-50
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Date Published | 2013 Jul
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ISSN | 1546-1726
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URL | |
DOI | 10.1038/nn.3435
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PubMed ID | 23708142
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PubMed Central ID | PMC3703870
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Links | |
Grant list | R01 AG17917 / AG / NIA NIH HHS / United States
K24 AG035007 / AG / NIA NIH HHS / United States
U24 AG021886 / AG / NIA NIH HHS / United States
K25 AG041906 / AG / NIA NIH HHS / United States
R01 AG030146 / AG / NIA NIH HHS / United States
P50 AG008702 / AG / NIA NIH HHS / United States
R01 AG043617 / AG / NIA NIH HHS / United States
P30 AG008051 / AG / NIA NIH HHS / United States
R10 NS067305 / NS / NINDS NIH HHS / United States
R01 AG017917 / AG / NIA NIH HHS / United States
P30 AG10161 / AG / NIA NIH HHS / United States
R01 NS067305 / NS / NINDS NIH HHS / United States
R25 GM076321 / GM / NIGMS NIH HHS / United States
R01 AG036042 / AG / NIA NIH HHS / United States
R01 AG11101 / AG / NIA NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
R01 AG15819 / AG / NIA NIH HHS / United States
RC2 GM093080 / GM / NIGMS NIH HHS / United States
P50 AG005138 / AG / NIA NIH HHS / United States
R01 AG30146 / AG / NIA NIH HHS / United States
R01 AG011101 / AG / NIA NIH HHS / United States
R01 AG031553 / AG / NIA NIH HHS / United States
R01 AG015819 / AG / NIA NIH HHS / United States
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