You are here

Nature neuroscience DOI:10.1038/nn.3435

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Publication TypeJournal Article
Year of Publication2013
AuthorsBradshaw, EM, Chibnik, LB, Keenan, BT, Ottoboni, L, Raj, T, Tang, A, Rosenkrantz, LL, Imboywa, S, Lee, M, Von Korff, A, Alzheimer Disease Neuroimaging, I, Morris, MC, Evans, DA, Johnson, K, Sperling, RA, Schneider, JA, Bennett, DA, De Jager, PL
JournalNature neuroscience
Volume16
Issue7
Pages848-50
Date Published2013/07/01
ISSN1097-6256
Abstract

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, Pjoint = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

URLhttp://dx.doi.org/10.1038/nn.3435
DOI10.1038/nn.3435
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23708142?dopt=Abstract