|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Gerard, B, Lee MD, 4th, Dandapani, S, Duvall, JR, Fitzgerald, ME, Kesavan, S, Lowe, JT, Marié, JC, Pandya, BA, Suh, BC, O'Shea, MW, Dombrowski, M, Hamann, D, Lemercier, B, Murillo, T, Akella, LB, Foley, MA, Marcaurelle, LA|
|Journal||The Journal of organic chemistry|
A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and methyl ester for further diversification via amine capping and amide coupling. Scaffold diversity was evaluated in comparison to previously prepared scaffolds by a shape-based principal moments of inertia (PMI) analysis.