You are here

Cell Res DOI:10.1038/cr.2013.68

RhoGTPases--NODes for effector-triggered immunity in animals.

Publication TypeJournal Article
Year of Publication2013
AuthorsStuart, LM, Boyer, L
JournalCell Res
Volume23
Issue8
Pages980-1
Date Published2013 Aug
ISSN1748-7838
KeywordsAnimals, Female, Humans, Male, Nod1 Signaling Adaptor Protein, rho GTP-Binding Proteins, Salmonella typhimurium
Abstract

A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observations made in flies and plants, establishing the evolutionary conservation of this detection system in the innate immune arsenal in many taxa.

URLhttp://dx.doi.org/10.1038/cr.2013.68
DOI10.1038/cr.2013.68
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23689278?dopt=Abstract

Alternate JournalCell Res.
PubMed ID23689278
PubMed Central IDPMC3731559
Grant ListP30 DK043351 / DK / NIDDK NIH HHS / United States