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Cell research DOI:10.1038/cr.2013.68

RhoGTPases - NODes for effector-triggered immunity in animals.

Publication TypeJournal Article
Year of Publication2013
AuthorsStuart, LM, Boyer, L
JournalCell research
Date Published2013/05/21

A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observations made in flies and plants, establishing the evolutionary conservation of this detection system in the innate immune arsenal in many taxa.