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Trends Immunol DOI:10.1016/j.it.2013.03.004

Immunological Genome Project and systems immunology.

Publication TypeJournal Article
Year of Publication2013
AuthorsShay, T, Kang, J
JournalTrends Immunol
Volume34
Issue12
Pages602-9
Date Published2013 Dec
ISSN1471-4981
KeywordsAnimals, Cell Lineage, Gene Regulatory Networks, Hematopoiesis, Humans, Signal Transduction, Transcriptome
Abstract

Immunological studies of single proteins in a single cell type have been complemented in recent years by larger studies, enabled by emerging high-throughput technologies. This trend has recently been exemplified by the discovery of gene networks controlling regulatory and effector αβ T cell subset development and human hematopoiesis. The Immunological Genome Project (ImmGen) aims to decipher the gene networks underpinning mouse hematopoiesis. The first phase, completed in 2012, profiled the transcriptome of 249 immune cell types. We discuss the utilities of the datasets in high-resolution mapping of the hematopoietic system. The immune transcriptome compendium has revealed unsuspected cell lineage relations and the network reconstruction has identified novel regulatory factors of hematopoiesis.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1471-4906(13)00049-5
DOI10.1016/j.it.2013.03.004
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23631936?dopt=Abstract

Alternate JournalTrends Immunol.
PubMed ID23631936
PubMed Central IDPMC4615706
Grant ListAI101301 / AI / NIAID NIH HHS / United States
CA100382 / CA / NCI NIH HHS / United States
AI072073 / AI / NIAID NIH HHS / United States
R01 CA100382 / CA / NCI NIH HHS / United States
R24 AI072073 / AI / NIAID NIH HHS / United States
R01 AI101301 / AI / NIAID NIH HHS / United States