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PLoS One DOI:10.1371/journal.pone.0060780

Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal.

Publication TypeJournal Article
Year of Publication2013
AuthorsDaniels, R, Chang, H-H, Séne, PDiogoye, Park, DC, Neafsey, DE, Schaffner, SF, Hamilton, EJ, Lukens, AK, Van Tyne, D, Mboup, S, Sabeti, PC, Ndiaye, D, Wirth, DF, Hartl, DL, Volkman, SK
JournalPLoS One
Date Published2013
KeywordsDNA Barcoding, Taxonomic, Epidemics, Genetic Linkage, Genotype, Humans, Malaria, Falciparum, Multilocus Sequence Typing, Plasmodium falciparum, Population Density, Prevalence, Seasons, Senegal

Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria control interventions and decreased malaria deaths. Parasite genotypes in some cases persisted clonally across dry seasons. The increase in frequency of genetically identical parasite strains corresponded with decrease in the probability of multiple infections. Further, these observations support evidence of both clonal and epidemic population structures. These data provide the first evidence of a temporal correlation between the appearance of identical parasite types and increased malaria control efforts in Africa, which here included distribution of insecticide treated nets (ITNs), use of rapid diagnostic tests (RDTs) for malaria detection, and deployment of artemisinin combination therapy (ACT). Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign.


Alternate JournalPLoS ONE
PubMed ID23593309
PubMed Central IDPMC3617153
Grant ListD43TW001503 / TW / FIC NIH HHS / United States
T32 AI007535 / AI / NIAID NIH HHS / United States
1R01AI075080-01A1 / AI / NIAID NIH HHS / United States
5R01GM061351 / GM / NIGMS NIH HHS / United States
T32 AI007638 / AI / NIAID NIH HHS / United States
R01 AI099105 / AI / NIAID NIH HHS / United States
1R56AI082589 / AI / NIAID NIH HHS / United States