Long noncoding RNAs regulate adipogenesis.

Proc Natl Acad Sci U S A
Authors
Keywords
Abstract

The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 175 lncRNAs that are specifically regulated during adipogenesis. Many lncRNAs are adipose-enriched, strongly induced during adipogenesis, and bound at their promoters by key transcription factors such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (CEBPα). RNAi-mediated loss of function screens identified functional lncRNAs with varying impact on adipogenesis. Collectively, we have identified numerous lncRNAs that are functionally required for proper adipogenesis.

Year of Publication
2013
Journal
Proc Natl Acad Sci U S A
Volume
110
Issue
9
Pages
3387-92
Date Published
2013 Feb 26
ISSN
1091-6490
DOI
10.1073/pnas.1222643110
PubMed ID
23401553
PubMed Central ID
PMC3587215
Links
Grant list
DP2 OD006670 / OD / NIH HHS / United States
P01 GM099117 / GM / NIGMS NIH HHS / United States
R37 DK047618 / DK / NIDDK NIH HHS / United States
1DP2OD00667 / OD / NIH HHS / United States
DK068348 / DK / NIDDK NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States
R56 DK068348 / DK / NIDDK NIH HHS / United States
R01 DK068348 / DK / NIDDK NIH HHS / United States
P50 HG006193 / HG / NHGRI NIH HHS / United States
P50HG006193-01 / HG / NHGRI NIH HHS / United States
R01 ES020260 / ES / NIEHS NIH HHS / United States
DK047618 / DK / NIDDK NIH HHS / United States
P01 HL066105 / HL / NHLBI NIH HHS / United States
5P01HL066105 / HL / NHLBI NIH HHS / United States
R01 DK047618 / DK / NIDDK NIH HHS / United States