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Cell stem cell DOI:10.1016/j.stem.2013.02.004

An Inflammatory Situation: SOX2 and STAT3 Cooperate in Squamous Cell Carcinoma Initiation.

Publication TypeJournal Article
Year of Publication2013
AuthorsBass, AJ, Wang, TC
JournalCell stem cell
Volume12
Issue3
Pages266-8
Date Published2013/03/07
ISSN1934-5909
Abstract

Although SOX2 has been identified as a squamous cell carcinoma oncogene, mechanisms of SOX2-induce oncogenesis have remained elusive. In this issue of Cell Stem Cell, Li et al. (2013) show that SOX2 synergizes with inflammation-induced STAT3 activation to transform basal progenitors and initiate squamous cell carcinoma.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1934-5909(13)00059-3
DOI10.1016/j.stem.2013.02.004
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23472866?dopt=Abstract