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Nature reviews. Immunology DOI:10.1038/nri3398

Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.

Publication TypeJournal Article
Year of Publication2013
AuthorsStuart, LM, Paquette, N, Boyer, L
JournalNature reviews. Immunology
Volume13
Issue3
Pages199-206
Date Published2013/03/01
ISSN1474-1733
Abstract

A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to sense perturbations in host cells induced by bacterial toxins or 'effectors' that are encoded by pathogenic microorganisms. Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy.

URLhttp://dx.doi.org/10.1038/nri3398
DOI10.1038/nri3398
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23411798?dopt=Abstract