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Nat Rev Immunol DOI:10.1038/nri3398

Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.

Publication TypeJournal Article
Year of Publication2013
AuthorsStuart, LM, Paquette, N, Boyer, L
JournalNat Rev Immunol
Date Published2013 03
KeywordsAnimals, Arabidopsis, Arabidopsis Proteins, Bacteria, Bacterial Infections, Bacterial Proteins, Flagella, Host-Pathogen Interactions, Humans, Immunity, Innate, Immunologic Surveillance, Metagenome, Models, Immunological, Protein Biosynthesis, Protein Kinases, Receptors, Pattern Recognition, Signal Transduction, Toll-Like Receptors, Virulence

A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to sense perturbations in host cells induced by bacterial toxins or 'effectors' that are encoded by pathogenic microorganisms. Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy.


Alternate JournalNat. Rev. Immunol.
PubMed ID23411798
PubMed Central IDPMC4121468
Grant ListR01 AI079198 / AI / NIAID NIH HHS / United States
R01 GM102482 / GM / NIGMS NIH HHS / United States
U54 AI057159 / AI / NIAID NIH HHS / United States