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Proc Natl Acad Sci U S A DOI:10.1073/pnas.1222738110

Conservation and divergence in the transcriptional programs of the human and mouse immune systems.

Publication TypeJournal Article
Year of Publication2013
AuthorsShay, T, Jojic, V, Zuk, O, Rothamel, K, Puyraimond-Zemmour, D, Feng, T, Wakamatsu, E, Benoist, C, Koller, D, Regev, A
Corporate AuthorsImmGen Consortium
JournalProc Natl Acad Sci U S A
Date Published2013 Feb 19
KeywordsAnimals, Gene Expression Profiling, Humans, Immune System, Lymphocyte Activation, Mice, T-Lymphocytes, Transcription, Genetic

Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are conserved, particularly for lineage-specific genes. However, several hundred genes show clearly divergent expression across the examined cell lineages, and among them, 169 genes did so even with highly stringent criteria. Finally, regulatory mechanisms--reflected by regulators' differential expression or enriched cis-elements--are conserved between the species but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.


Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID23382184
PubMed Central IDPMC3581886
Grant ListU54-CA149145 / CA / NCI NIH HHS / United States
P30 DK026743 / DK / NIDDK NIH HHS / United States
RC2 GM093080 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R24 AI072073 / AI / NIAID NIH HHS / United States
U54 CA149145 / CA / NCI NIH HHS / United States
RC2-GM093080 / GM / NIGMS NIH HHS / United States