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Trends Microbiol DOI:10.1016/j.tim.2012.12.004

Eukaryotic virulence determinants utilize phosphoinositides at the ER and host cell surface.

Publication TypeJournal Article
Year of Publication2013
AuthorsH Y Jiang, R, Stahelin, RV, Bhattacharjee, S, Haldar, K
JournalTrends Microbiol
Volume21
Issue3
Pages145-56
Date Published2013 Mar
ISSN1878-4380
KeywordsAmino Acid Motifs, Cell Membrane, Endoplasmic Reticulum, Host-Pathogen Interactions, Humans, Phosphatidylinositols, Phytophthora infestans, Plants, Plasmodium falciparum, Protein Binding, Virulence Factors
Abstract

Similar to bacteria, eukaryotic pathogens may utilize common strategies of pathogenic secretion, because effector proteins from the oomycete Phytophthora infestans and virulence determinants from the human malaria parasite Plasmodium falciparum share a functionally equivalent host-cell-targeting motif (RxLR-dEER in P. infestans and RxLxE/D/Q in P. falciparum). Here we summarize recent studies that reveal that the malarial motif may function differently than previously envisioned. Binding of the lipid phosphatidylinositol 3-phosphate [PI(3)P] is a critical step in accessing the host for both pathogens, but occurs in different locations. Nanomolar affinity for PI(3)P by these short amino acid motifs suggests that a newly identified mechanism of phosphoinositide binding that unexpectedly occurs in secretory locations has been exploited for virulence by diverse eukaryotic pathogens.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0966-842X(12)00227-2
DOI10.1016/j.tim.2012.12.004
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23375057?dopt=Abstract

Alternate JournalTrends Microbiol.
PubMed ID23375057
PubMed Central IDPMC3595378
Grant ListAI039071 / AI / NIAID NIH HHS / United States
HL069630 / HL / NHLBI NIH HHS / United States
R01 AI081077 / AI / NIAID NIH HHS / United States
HL078826 / HL / NHLBI NIH HHS / United States
R01 HL069630 / HL / NHLBI NIH HHS / United States
AI081077 / AI / NIAID NIH HHS / United States
P01 HL078826 / HL / NHLBI NIH HHS / United States
R01 AI039071 / AI / NIAID NIH HHS / United States