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Nat Genet DOI:10.1038/ng.2522

Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.

Publication TypeJournal Article
Year of Publication2013
AuthorsChmielecki, J, Crago, AM, Rosenberg, M, O'Connor, R, Walker, SR, Ambrogio, L, Auclair, D, McKenna, A, Heinrich, MC, Frank, DA, Meyerson, M
JournalNat Genet
Date Published2013 Feb
KeywordsBase Sequence, Exome, Gene Components, Gene Fusion, Genetic Variation, Humans, Molecular Sequence Data, Neoplasm Proteins, Repressor Proteins, Sequence Analysis, DNA, Solitary Fibrous Tumors, STAT6 Transcription Factor

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.


Alternate JournalNat. Genet.
PubMed ID23313954
PubMed Central IDPMC3984043
Grant ListP01 CA047179 / CA / NCI NIH HHS / United States
P50 CA140146 / CA / NCI NIH HHS / United States
P01CA47179 / CA / NCI NIH HHS / United States